January Jones as Mrs Brisby
Alfred Molina as Nicodemus
Charlie Day as Mr. Ages
Mike Myers as Jeremy
Miriam Margolyes as Auntie Shrew
Morgan Freeman as The Great Owl
Johnny Depp as Justin
Cedric the Entertainer as Jenner
Taylar Hender as Teresa Brisby
Hugh Jackman as Farmer Fitzgibbons
Mandy Moore as Miss Right
Megan Mullally as Mrs Fitzgibbons
Jonah Bobo as Martin Brisby